05 January 2017
ITN European Industrial Doctorates Grant
Associate Professor Kasper D. Rand, Department of Pharmacy, has received DKK 4.3 million from The Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry.
Associate Professor Kasper D. Rand from Section of Analytical Biosciences at Department of Pharmacy and grant partner Natalie Norais, GlaxoSmithKline, have received a grant from VADEMA (Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry). The grant share for Department of Pharmacy is DKK 4.3 million.
VADEMA is a European Industrial Doctorate (EID) funded by the Marie Skłodowska-Curie Actions of Horizon 2020, with the aim of training four young scientists in the structural mass spectrometry and vaccinology fields.
Vaccines consisting of live-attenuated microorganisms or purified protein components (antigens) have led to the successful control of many devastating diseases. However, despite decades of research, vaccines still do not exist for several of the most life-threatening infections.
An effective immune response requires the exposure of key parts of the protein antigen (the epitope) to the binding of antibodies. Thus careful analysis of the structure of vaccine antigens combined with knowledge of where antibodies bind the protein antigen to cause protection has emerged as a powerful new strategy for the rational vaccine design.
In this research programme, we will develop and apply new and advanced analytical methodology that uses mass spectrometry to measure the hydrogen/deuterium exchange of proteins in solution (HDX-MS) to better understand the dynamic structure and antibody interactions of a range of promising vaccine antigens. From this work, we hope to provide a unique framework for improving and guiding the design of new protein-based vaccines.
Job advertisement regarding the four PhD positions included in the grant:
Call for 4 Early Stage Researcher Fellowships in "Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry"