Researchers at Department of Pharmacy develop novel cell line for screening of brain drugs – University of Copenhagen

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19 January 2016

Researchers at Department of Pharmacy develop novel cell line for screening of brain drugs

Brain

Researchers from the Department of Pharmacy at the University of Copenhagen have developed a cell line, which may be used to investigate new drugs and help predict whether they are able to enter the brain. The research has recently been published in the renowned pharmaceutical journal Molecular Pharmaceutics.

A research group from the Department of Pharmacy have developed a cell line, which may be used to investigate new drugs and help predict whether they are able to enter the brain.
The brain is protected by the so-called blood-brain barrier, a practically impermeable wall in the brain’s blood vessels. This dense wall contains lots of proteins, which act as efflux pumps for numerous drug compounds.

The new cell line can help other scientists as well as the pharmaceutical industry when they investigate whether or not newly developed drug compounds can enter the brain and/or tumor tissue where the pump normally acts to keep drugs out.

The research has recently been published in the renowned pharmaceutical journal Molecular Pharmaceutics.

More info at the website Faculty of Health and Medical Sciences, UCPH:
Researchers develop novel cell line for screening of brain drugs.

Read the scientific article in Molecular Pharmaceuticals (login may be required):
IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies.