Employees – University of Copenhagen

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Department of Pharmacy > Employees

Esben Trabjerg

Esben Trabjerg

Industrial PhD

H. Lundbeck A/S is developing treatments targeting neurodegenerative diseases. Several of the drugs in Lundbecks pipeline are monoclonal antibodies (mAbs). My task is to identify the epitope of several of these mAbs by employing the highly sensitive analytical method hydrogen/deuterium exchange followed by mass spectrometry.

Furthermore, in the Protein Analysis Group, Department of Pharmacy, University of Copenhagen my work focuses on development and improvement of mass spectrometric methods for probing the primary and higher-order structure of proteins and protein-complexes, especially HDX-MS.

Group webpage:
www.pharmacy.ku.dk/research/section_analytical_biosciences/protein_analysis-lab/

Primary fields of research

  • Analysis of the primary and higher-order structure of proteins by LC-MS/MS
  • Identification of protein-protein interaction sites
  • Higher-order structure elucidation of proteins by hydrogen/deuterium exchange followed by mass spectrometry (HDX-MS)
  • Epitope mapping of antibodies by HDX-MS
  • Higher-order structure elucidation of proteins by cross linking mass spectrometry (CX-MS)
  • Development of the HDX-MS method
  • Upstream and downstream processing of therapeutic proteins.

ID: 131811990