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Department of Pharmacy > Employees

Stine Harloff-Helleberg

Stine Harloff-Helleberg

Postdoc

Stine is Postdoc at Section for Biologics at the Department of Pharmacy, University of Copenhagen. She holds a Master in Pharmaceutical Sciences from University of Copenhagen and a PhD in food biophysics from the Faculty of Science, University of Copenhagen.

For the last 7 years, Stine has been working in academia including both research in close collaboration with the industry (Arla during the PhD and as an external Novo Nordisk fellow during her postdoc), lecturing and supervision of especially master students. Also, she has developed teaching material for Development of teaching material to the European Patients' Academy Expert Training Course for Patients and Patient Representatives (EUPATI) on the Medicines Research & Development Process.

Based on a master project at LEO Pharma focusing on cutaneous drug delivery of small molecules including use of ex vivo skin models, her PhD was within physico-chemical characterization of fat-based emulsions including utilization of large synchrotron facilities. With this interdisciplinary background, Stine moved on to a postdoc in the field of oral delivery of large molecules, especially focusing on in vitro and in vivo evaluation hereof. During her PhD, she extensively used advanced physical and biophysical analytical, all highly applicable to development and characterization of the physico-chemical behavior of drug delivery systems (DDS). Stine’s current work includes development of DDS primarily being hydrogels including permeation enhancers such as lipids, membrane modulating peptides and cell penetrating peptides. The work is with a particular focus on a detailed understanding of the physico-chemical structure of DDS is key to fully to understand their mechanistic behavior in vitro and in vivo. Also, focus is on the mechanistic behavior, safety, kinetics and dynamics of the DDS has subsequently been studied using advanced in vitro models and in complex in vivo models.

Stine is currently associated to employed on an EU project, COMPACT, where she is Project leader and responsible for in vitro and in vivo methodology. In relation to this, she holds of an in vivo license which includes monitoring and approval of protocols used under the license, quality assurance of the technical skills of the people working under the license, assurance of ethical aspects in agreement with both legislation and license, yearly reporting to the Animal Experiments Inspectorate, The Ministry of Environment and Food of Denmark.

Selected publications

  1. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

    Rønholt, S., Kristensen, M. & Nielsen, H. M. 2015 Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324, Ch. 17, p. 261-277 17 p.

    Publication: Research - peer-reviewBook chapter

  2. Published

    The effect of butter grains on physical properties of butter-like emulsions

    Rønholt, S., Buldo, P., Mortensen, K., Andersen, U., Knudsen, J. C. & Wiking, L. 2014 In : Journal of Dairy Science. 97, 4, p. 1929-1938 10 p.

    Publication: Research - peer-reviewJournal article

  3. Published

    Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber

    Rønholt, S., Knudsen, J. C. & Mortensen, K. 2013 In : Dansk Kemi. 94, 11, p. 33-34 2 p.

    Publication: CommunicationJournal article

  4. Published

    Fat crystallization in dairy products: Rheology and microstructure of fat crystals

    Rønholt, S. 2013 Department of Food Science, University of Copenhagen. 283 p.

    Publication: ResearchPh.D. thesis

  5. Published

    Effect of cream cooling rate and water content on butter microstructure during four weeks of storage

    Rønholt, S., Kirkensgaard, J. J. K., Mortensen, K. & Knudsen, J. C. 2014 In : Food Hydrocolloids. 34, p. 169-176 8 p.

    Publication: Research - peer-reviewJournal article

  6. Published

    The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter

    Rønholt, S., Kirkensgaard, J. J. K., Høyer, K. F., Mortensen, K. & Knudsen, J. C. 2014 In : Journal of the American Oil Chemists' Society. 91, 1, p. 29-38

    Publication: Research - peer-reviewJournal article

  7. Published

    The effective factors on the structure of butter and other milk fat-based products

    Rønholt, S., Mortensen, K. & Knudsen, J. C. 2013 In : Comprehensive Reviews in Food Science and Food Safety. 12, 5, p. 468-482 15 p.

    Publication: Research - peer-reviewJournal article

  8. Published

    Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples

    Rønholt, S., Mortensen, K. & Knudsen, J. C. 2014 In : Journal of Texture Studies. 45, 1, p. 20-29 10 p.

    Publication: Research - peer-reviewJournal article

  9. Published

    Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment

    Rønholt, S., Kirkensgaard, J. J. K., Pedersen, T. B., Mortensen, K. & Knudsen, J. C. 2012 In : Food Chemistry. 135, 3, p. 1730-1739 10 p.

    Publication: Research - peer-reviewJournal article

  10. Published
  11. Published

    Calcipotriol delivery into the skin with PEGylated liposomes

    Knudsen, N. Ø., Rønholt, S., Salte, R. D., Jorgensen, L., Thormann, T., Basse, L. H., Hansen, J., Frokjaer, S. & Foged, C. 2012 In : European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

    Publication: Research - peer-reviewJournal article

  12. Published

    Lipid-protein interactions in nanodiscs: how to enhance stability

    Wadsäter, M. H., Cardenas Gomez, M., Rønholt, S., Maric, S., Skar-Gislinge, N., Midtgaard, S. R., Arleth, L., Mortensen, K., Ryan, R. O. & Simonsen, J. B. 2012 In : Biophysical Journal. 102, 3, p. 236a 1 p.

    Publication: Research - peer-reviewConference abstract in journal

  13. Published

    Fedtstruktur: innovation af smør og blandingsprodukter

    Rønholt, S., Knudsen, J. C., Mortensen, K., Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U. 2012 In : Maelkeritidende. 6, p. 8-9 2 p.

    Publication: ResearchJournal article

  14. Published

    Danmark kan lære meget af australske erfaringer med klinisk farmaci

    Rønholt, S. 2008 In : Pharma. 7, p. 32-34 3 p.

    Publication: CommunicationJournal article

Selected activities

  1. 2014 AAPS Annual meeting and EXPO

    Harloff-Helleberg, S. (Speaker)
    2 Nov 20146 Nov 2014

    Activity: Participating in or organising an eventParticipation in workshop, seminar, course

  2. COMPACT

    Harloff-Helleberg, S. (Speaker)
    3 Feb 20155 Feb 2015

    Activity: Participating in or organising an eventParticipation in workshop, seminar, course

  3. EUPATI

    Harloff-Helleberg, S. (Speaker)
    1 Jan 2014 → …

    Activity: Participating in or organising an eventParticipation in workshop, seminar, course

  4. Cell Penetrating Peptides

    Harloff-Helleberg, S. (Participant)
    7 Oct 201313 Oct 2013

    Activity: Participating in or organising an eventParticipation in workshop, seminar, course

ID: 18182987