Drug Discovery and Development Targeting Dementia
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Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia.
Original language | English |
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Article number | 151 |
Journal | Pharmaceuticals |
Volume | 16 |
Issue number | 2 |
Number of pages | 19 |
ISSN | 1424-8247 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
Publication of this article was supported by the Excellence Initiative–Research University program for the University of Wrocław.
- dementia, drug discovery and development, nanocarriers
Research areas
ID: 339331514