Kasper Dyrberg Rand

Kasper Dyrberg Rand

Professor

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    ORCID: 0000-0002-6337-5489

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    1. Published

      A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

      Jensen, P. F., Schoch, A., Larraillet, V., Hilger, M., Schlothauer, T., Emrich, T. & Rand, Kasper Dyrberg, Mar 2017, In: Molecular and Cellular Proteomics. 16, 3, p. 451-456 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

      Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The dopamine transporter antiports potassium to increase the uptake of dopamine

      Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb

      Hudgens, J. W., Gallagher, E. S., Karageorgos, I., Anderson, K. W., Filliben, J. J., Huang, R. Y-C., Chen, G., Bou-Assaf, G. M., Espada, A., Chalmers, M. J., Harguindey, E., Zhang, H-M., Walters, B. T., Zhang, J., Venable, J. D., Steckler, C., Park, I., Brock, A., Lu, X., Pandey, R. K. & 17 others, Chandramohan, A., Anand, G. S., Nirudodhi, S. N., Sperry, J. B., Rouse, J. C., Carroll, J. A., Rand, Kasper Dyrberg, Leurs, U., Weis, D. D., Al-Naqshabandi, M. A., Hageman, T. S., Deredge, D., Wintrode, P. L., Papanastasiou, M., Lambris, J. D., Li, S. & Urata, S., 2019, In: Analytical Chemistry. 91, 11, p. 7336-7345

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

      Masson, G. R., Burke, J. E., Ahn, N. G., Anand, G. S., Borchers, C., Brier, S., Bou-Assaf, G. M., Engen, J. R., Englander, S. W., Faber, J., Garlish, R., Griffin, P. R., Gross, M. L., Guttman, M., Hamuro, Y., Heck, A. J. R., Houde, D., Iacob, R. E., Jorgensen, T. J. D., Kaltashov, I. A. & 20 others, Klinman, J. P., Konermann, L., Man, P., Mayne, L., Pascal, B. D., Reichmann, D., Skehel, M., Snijder, J., Strutzenberg, T. S., Underbakke, E. S., Wagner, C., Wales, T. E., Walters, B. T., Weis, D. D., Wilson, D. J., Wintrode, P. L., Zhang, Z., Zheng, J., Schriemer, D. C. & Rand, Kasper Dyrberg, Jul 2019, In: Nature Methods. 16, 7, p. 595-602

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling

      Bache, N., Rand, Kasper Dyrberg, Roepstorff, P. & Jørgensen, T., 2008, In: Analytical Chemistry. 80, 16, p. 6431-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

      Rand, Kasper Dyrberg, Andersen, M., Olsen, O. H., Jørgensen, T., Ostergaard, H., Jensen, O., Stennicke, H. R. & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 19, p. 13378-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

      Rand, Kasper Dyrberg, Jørgensen, T., Olsen, Ole, Persson, E., Jensen, O., Stennicke, H. R. & Andersen, M., 2006, In: Journal of Biological Chemistry. 281, 32, p. 23018-24 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry

      Hebling, C. M., Morgan, C. R., Stafford, D. W., Jorgenson, J. W., Rand, Kasper Dyrberg & Engen, J. R., 2010, In: Analytical Chemistry. 82, 13, p. 5415-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Pinpointing changes in higher-order protein structure by hydrogen/deuterium exchange coupled to electron transfer dissociation mass spectrometry

      Rand, Kasper Dyrberg, 15 Mar 2013, In: International Journal of Mass Spectrometry. 338, p. 2-10 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      A novel sensitive sheathless CE-MS device for peptide and protein analysis

      Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 8 Jun 2016. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    12. Published

      Conformational destabilization of Immunoglobulin G increases the low pH-binding affinity with the Neonatal Fc Receptor

      Walters, B. T., Jensen, P. F., Larraillet, V., Lin, K., Patapoff, T., Schlothauer, T., Rand, Kasper Dyrberg & Zhang, J., 22 Jan 2016, In: Journal of Biological Chemistry. 291, 4, p. 1817-1825 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

      Przygońska, K., Poznański, J., Mistarz, U. H., Rand, Kasper Dyrberg & Dadlez, M., 6 Aug 2018, In: PLoS One. 13, 8, p. 1-25 25 p., e0201761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling

      Rand, Kasper Dyrberg, Zehl, M. & Jørgensen, T. J. D., 21 Oct 2014, In: Accounts of Chemical Research. 47, 10, p. 3018-27 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

      Jensen, P. F., Larraillet, V., Schlothauer, T., Kettenberger, H., Hilger, M. & Rand, Kasper Dyrberg, Jan 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 148-61 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Molecular Basis of the Mechanisms Controlling MASTL

      Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

      Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      PNGase H+ variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N‐glycans and HDX‐MS analysis of glycoproteins.

      Guo, R., Zhang, T., Lambert, Thomas Ole Tandrup, Wang, T., Voglmeir, J., Rand, Kasper Dyrberg & Liu, L., 2022, In: Rapid Communications in Mass Spectrometry. 36, 21, 9 p., e9376.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Epitope Mapping of Polyclonal Antibodies by Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)

      Ständer, S., Grauslund, L. R., Scarselli, M., Norais, N. & Rand, Kasper Dyrberg, 2021, In: Analytical Chemistry. 93, 34, p. 11669–11678

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT

      Calugareanu, D., Möller, I. R., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      An intact C-terminal end of albumin is required for long serum half-life

      Nilsen, J., Trabjerg, E., Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., Dec 2019, p. 19. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    22. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

      Kim, M., Sun, Z. J., Rand, Kasper Dyrberg, Shi, X., Song, L., Cheng, Y., Fahmy, A. F., Majumdar, S., Ofek, G., Yang, Y., Kwong, P. D., Wang, J., Engen, J. R., Wagner, G. & Reinherz, E. L., 2011, In: Nature Structural and Molecular Biology. 18, 11, p. 1235-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

      Rand, Kasper Dyrberg, Pringle, S. D., Morris, M., Engen, J. R. & Brown, J. M., 2011, In: Journal of The American Society for Mass Spectrometry. 22, 10, p. 1784-1793

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'

      Fang, J., Rand, Kasper Dyrberg, Silva, M. C., Wales, T. E., Engen, J. R. & Beuning, P. J., 2010, In: Journal of Molecular Biology. 398, 1, p. 40-53 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

      Morgan, C. R., Hebling, C. M., Rand, Kasper Dyrberg, Stafford, D. W., Jorgenson, J. W. & Engen, J. R., 2011, In: Molecular and Cellular Proteomics. 10, 9, p. M111.010876

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

      Svensson, L. A., Bondensgaard, K., Nørskov-Lauritsen, L., Christensen, L., Becker, P., Andersen, M., Maltesen, M. J., Rand, Kasper Dyrberg, Breinholt, J. & Maltesen, M. J., 2008, In: Journal of Biological Chemistry. 283, 27, p. 19085-94 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

      Lafleur, J. P., Senkbeil, S., Novotny, J., Nys, G., Bøgelund, N., Rand, Kasper Dyrberg, Foret, F. & Kutter, Jörg P., 2015, In: Lab On a Chip. 15, 10, p. 2162-72 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Thiol-ene microfluidic chip for performing hydrogen/deuterium exchange of proteins at sub-second timescales

      Svejdal, R. R., Dickinson, E. R., Sticker, Drago, Kutter, Jörg P. & Rand, Kasper Dyrberg, 15 Jan 2019, In: Analytical Chemistry. 91, 2, p. 1309-1317

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

      Singh, H. R., Nardozza, A. P., Möller, I. R., Knobloch, G., Kistemaker, H. A. V., Hassler, M., Harrer, N., Blessing, C., Eustermann, S., Kotthoff, C., Huet, S., Mueller-Planitz, F., Filippov, D. V., Timinszky, G., Rand, Kasper Dyrberg & Ladurner, A. G., 7 Dec 2017, In: Molecular Cell. 68, 5, p. 860-871.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale

      Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11868-76 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Deglycosylation by the Acidic Glycosidase PNGase H+ Enables Analysis of N-Linked Glycoproteins by Hydrogen/Deuterium Exchange Mass Spectrometry

      Comamala, G., Madsen, J. B., Voglmeir, J., Du, Y., Jensen, P. F., Østerlund, E. C., Trelle, M. B. & Rand, Kasper Dyrberg, 2020, In: Journal of the American Society for Mass Spectrometry. 31, 11, p. 2305-2312

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Discovery of Highly Active Recombinant PNGase H+ Variants Through the Rational Exploration of Unstudied Acidobacterial Genomes

      Guo, R., Comamala, G., Yang, H., Gramlich, M., Du, Y., Wang, T., Zeck, A., Rand, Kasper Dyrberg, Liu, L. & Voglmeir, J., 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 7 p., 741.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Investigation of amide hydrogen back-exchange in Asp and His repeats measured by hydrogen (1H/2H) exchange mass spectrometry

      Rand, Kasper Dyrberg, Lund, F. W., Amon, S. & Jørgensen, Thomas, Apr 2011, In: International Journal of Mass Spectrometry.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Back Cover: Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry (ChemBioChem 11/2017)

      Leurs, U., Beck, H., Bonnington, L., Lindner, I., Pol, E. & Rand, Kasper Dyrberg, 1 Jun 2017, In: ChemBioChem.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Hydrogen/Deuterium Exchange Mass Spectrometry with Integrated Electrochemical Reduction and Microchip-Enabled Deglycosylation for Epitope Mapping of Heavily Glycosylated and Disulfide-Bonded Proteins

      Comamala, G., Krogh, C. C., Nielsen, V. S., Kutter, Jörg P., Voglmeir, J. & Rand, Kasper Dyrberg, 2021, In: Analytical Chemistry. 93, 49, p. 16330–16340

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

      Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

      Liew, C. W., Rand, Kasper Dyrberg, Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M. & Mackay, J. P., 2006, In: Journal of Biological Chemistry. 281, 38, p. 28296-306 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dessociation

      Rand, Kasper Dyrberg, Pringle, S. D., Morris, M. & Brown, J. M., 2012, In: Analytical Chemistry. 84, 4, p. 1931-1940

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Loss of ammonia during electron-transfer dissociation of deuterated peptides as an inherent gauge of gas-phase hydrogen scrambling

      Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2010, In: Analytical Chemistry. 82, 23, p. 9755-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

      Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Feb 2016, In: Structure. 24, 2, p. 310-318 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

      Grauslund, L. R., Calvaresi, V., Pansegrau, W., Norais, N. & Rand, Kasper Dyrberg, 2021, In: Journal of the American Society for Mass Spectrometry. 32, 7, p. 1575–1582

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Installation, validation, and application examples of two instrumental setups for gas-phase HDX-MS analysis of peptides and proteins

      Mistarz, U. H. & Rand, Kasper Dyrberg, 15 Jul 2018, In: Methods. 144, p. 113-124

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

      Parker, C. H., Morgan, C. R., Rand, Kasper Dyrberg, Engen, J. R., Jorgenson, J. W. & Stafford, D. W., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1511-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Investigating surrogate cerebrospinal fluid matrix compositions for use in quantitative LC-MS analysis of therapeutic antibodies in the cerebrospinal fluid

      Fogh, J. R., Jacobsen, A., Nguyen, T. T. T. N., Rand, Kasper Dyrberg & Olsen, L. R., 2020, In: Analytical and Bioanalytical Chemistry. 412, p. 1653-1661

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation

      Seger, S. T., Breinholt, J., Faber, J. H., Andersen, M. D., Wiberg, C., Schjødt, C. B. & Rand, Kasper Dyrberg, 16 Jun 2015, In: Analytical Chemistry. 87, 12, p. 5973-80 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Substrate-induced conformational dynamics of the dopamine transporter

      Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

      Rand, Kasper Dyrberg, Adams, C. M., Zubarev, R. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 4, p. 1341-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

      Rand, Kasper Dyrberg & Jørgensen, T., 2007, In: Analytical Chemistry. 79, 22, p. 8686-93 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry

      Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2009, In: Analytical Chemistry. 81, 14, p. 5577-84 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

      Zehl, M., Rand, Kasper Dyrberg, Jensen, O. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 51, p. 17453-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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